An urgent challenge this 21st century is ending hunger and malnutrition in sub-Saharan Africa (SSA) by 2030. Agricultural productivity is very low in SSA, which has the highest population growth rate globally, and is challenged by a myriad of problems including deteriorating soils, increasing pest and disease problems, drought, exacerbated by climate change. Extensive research reports indicate that productivity of the staple crops of SSA would need to be increased by 80% by 2050 to feed a burgeoning population. This would require significant investments in science and technology and strategic public-private partnerships for the development of improved, climate-smart crops with in-built resilience against biotic and abiotic stresses that meet market and industry demand. It is against this backdrop that the West Africa Centre for Crop Improvement (WACCI), a World Bank funded Africa Centre of Excellence (ACE) and a leader in plant breeding education in Africa is organizing an International Conference on Food and Nutrition Security dubbed “The march towards a hunger-free Africa” in commemoration of the 70th anniversary of the University of Ghana. The Conference will provide a platform for conversations on research outcomes and development of partnerships for the inclusive transformation of agriculture in SSA. It is expected that concrete and concerted actions required to realize a SSA free from hunger and malnutrition would be mobilized.